Water → 2-Hydroxy-3'-(trifluoromethyl)acetophenone

HRID 2427152Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427152
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[OH2:15]>C(#N)C>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][OH:15])[CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one

Produkt 1

HCID 167269582-Hydroxy-3'-(trifluoromethyl)acetophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 2-bromo-1-[3-(trifluoromethyl)phenyl]ethanone (1 g) in acetonitrile (2.5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min) The same experiment is repeated five times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Aufarbeitung

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-37864011259241ecb0ef92d8b420cb85
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968581B2

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