Methanol → Methyl 2-iodo-6-methylbenzoate

HRID 2427580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427580
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4]([OH:6])=[O:5].[C:12](Cl)(=O)C(Cl)=O.CO.C(N(CC)CC)C>ClCCl.CN(C)C=O>[CH3:12][O:5][C:4](=[O:6])[C:3]1[C:7]([CH3:11])=[CH:8][CH:9]=[CH:10][C:2]=1[I:1]

Komponenten

7

Edukt 4

HCID 887MethanolHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 98565312-Iodo-6-methylbenzoic acid

Produkt 1

HCID 23655277Methyl 2-iodo-6-methylbenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-iodo-6-methyl-benzoic acid (3.42 g, 13 mmol) in dichloromethane (25 mL) was treated with oxalyl chloride (7.5 mL, 15 mmol) and dimethylformamide (several drops) followed by treatment with methanol (30 mL) and triethylamine (2.78 mL, 20 mmol). Workup afforded 2-iodo-6-methyl-benzoic acid methyl ester. The material was used without further purification.

Quellen und Nachweise

ORD-Eintrag
ord-6f594cd6fe804ba99c6007f416d0a69b
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968570B2

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