Benzoyl Peroxide → Methyl 4-bromo-2-(bromomethyl)-6-chlorobenzoate

HRID 2427645Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427645
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Br:11])=[CH:6][C:5]=1[Cl:12].[Br:14]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5]([Cl:12])=[CH:6][C:7]([Br:11])=[CH:8][C:9]=1[CH2:10][Br:14]

Komponenten

5

Edukt 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 45480505Methyl 4-bromo-2-chloro-6-methylbenzoate

Produkt 1

HCID 59512234Methyl 4-bromo-2-(bromomethyl)-6-chlorobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A mixture of 4-bromo-2-chloro-6-methyl-benzoic acid methyl ester (2.447 g, 9.27 mmol,), N-bromosuccinimide (1.815 g, 10.2 mmol), and benzoyl peroxide (0.051 g, 0.22 mmol) in carbon tetrachloride (30 mL) was refluxed until most of the starting materials were consumed (as analyzed by GC/MS). The resulting mixture was filtered and the filtrate concentrated to afford 4-bromo-2-bromomethyl-6-chloro-benzoic acid methyl ester. The product was used without further purification.

Aufarbeitung

  1. temperaturewas refluxed until most of the starting materials
  2. customwere consumed (as analyzed by GC/MS)
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate concentrated

Quellen und Nachweise

ORD-Eintrag
ord-3cfd6acd75324c6e98fe2e700e3d8aa4
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968570B2

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