Benzoyl Peroxide → 2-Bromomethyl-4,6-dichlorobenzoic acid methyl ester

HRID 2427750Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427750
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([CH3:10])=[CH:8][C:7]([Cl:11])=[CH:6][C:5]=1[Cl:12].[Br:14]NC(=O)CCC(N)=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5]([Cl:12])=[CH:6][C:7]([Cl:11])=[CH:8][C:9]=1[CH2:10][Br:14]

Komponenten

5

Edukt 3

HCID 7187Benzoyl PeroxideHCID 9834204N-BromosuccinamideHCID 57949430Methyl 2,4-dichloro-6-methylbenzoate

Produkt 1

HCID 579493492-Bromomethyl-4,6-dichlorobenzoic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A mixture of 2,4-dichloro-6-methyl-benzoic acid methyl ester (0.71 g, 3.23 mmol), N-bromosuccinamide (0.693 g, 3.9 mmol), and benzoyl peroxide (0.012 g, 0.05 mmol) in carbon tetrachloride (20 mL) was heated at reflux until majority of ester was consumed (as analyzed by GC/MS). The resulting mixture was filtered, the filtrate was concentrated to afford 2-Bromomethyl-4,6-dichloro-benzoic acid methyl ester. The material was used without further purification.

Aufarbeitung

  1. temperaturewas heated
  2. customwas consumed (as analyzed by GC/MS)
  3. filtrationThe resulting mixture was filtered
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-d02f25935f2e4e34831f30b3de573bff
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968570B2

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