Potassium Hydroxide → 4-Chloro-5-hydroxy-2-phenylpyridazin-3(2H)-one

HRID 2427790Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427790
[Cl:1][C:2]1[C:3](=[O:15])[N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1Cl.[OH-:16].[K+]>C(O)C.O>[Cl:1][C:2]1[C:3](=[O:15])[N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1[OH:16]

Komponenten

5

Edukt 2

HCID 14797Potassium HydroxideHCID 728134,5-Dichloro-2-phenyl-3(2H)-pyridazinone

Produkt 1

HCID 546957994-Chloro-5-hydroxy-2-phenylpyridazin-3(2H)-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

4,5-Dichloro-2-phenylpyridazin-3-one (2.4 g, 0.01 moles) was suspended in ethanol (50 ml) and potassium hydroxide (2.0 g, 0.03 moles) was added in water (20 ml). Refluxed for 4 hours. Evaporated to dryness and added water. Acidified to pH2 with c. hydrochloric acid. Filtered off the product as a buff solid and dried in a desiccator. (2.1 g) Took 0.5 g and dissolved in methanol, filtered and evaporated. Triturated with ether to give the product as a cream solid. (0.4 g, 76%)

Aufarbeitung

  1. temperatureRefluxed for 4 hours
  2. customEvaporated to dryness
  3. additionadded water
  4. filtrationFiltered off the product as a buff solid
  5. customdried in a desiccator
  6. dissolution(2.1 g) Took 0.5 g and dissolved in methanol
  7. filtrationfiltered
  8. customevaporated
  9. customTriturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-76d3a6e59eaa445880ac9b33d7d594ee
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968711B2

Notizen zur Reaktion

Wird geladen…