Ammonium Hydroxide → 2-Oxoindoline-5-sulfonamide

HRID 24310

Reaktionsgleichung

Reaktionsgleichung von HRID 24310
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[OH-].[NH4+:16]>C(O)C>[NH2:16][S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 49625062-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

Produkt 1

HCID 101982322-Oxoindoline-5-sulfonamideAusbeute 20 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5-Chlorosulfonyl-2-oxindole (2.1 g) was added to 10 mL of ammonium hydroxide in 10 mL of ethanol and stirred at room temperature overnight. The mixture was concentrated and the solid collected by vacuum filtration to give 0.4 g (20% yield) of the title compound as an off-white solid.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. filtrationthe solid collected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-2520af5761ac4f8b8d7b07549287ce02
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855730B2

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