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Dimethylformamide → N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide

HRID 243635
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 243635
C1(S(O[CH2:11][CH2:12][C:13]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=3)[CH:16]=[CH:15][CH:14]=2)(=O)=O)C=CC=CC=1.[C:25]1(=[O:35])[NH:29][C:28](=[O:30])[C:27]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:26]12.[K].CN(C)C=O>O>[CH3:24][O:23][C:20]1[CH:21]=[C:22]2[C:17]([CH:16]=[CH:15][CH:14]=[C:13]2[CH2:12][CH2:11][N:29]2[C:28](=[O:30])[C:27]3=[CH:31][CH:32]=[CH:33][CH:34]=[C:26]3[C:25]2=[O:35])=[CH:18][CH:19]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 135700677-Methoxy-1-naphthylethyl benzene sulfonateHCID 24194345Phthalimide potassium salt

Produkt 1

HCID 44633448N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The compound IV (14 g, 0.041 mol) produced as described above and potassium phthalimide (13 g, 0.0738 mol) were added into a reaction vessel, and dimethylformamide (200 ml) was added. The mixture was heated and refluxed for 2 hours. After cooling it to room temperature, 200 ml of water was added, and the mixture was stirred and filtered. The filter cake formed was washed with water and dried, to produce 11.9 g of N-[2-(7-methoxy-1-naphthyl)ethyl]phthalimide (II). The yield was 88%. The melting point was 160-161° C.

Aufarbeitung

  1. additionwere added into a reaction vessel
  2. temperatureThe mixture was heated
  3. temperaturerefluxed for 2 hours
  4. filtrationfiltered
  5. customThe filter cake formed
  6. washwas washed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e303be1ca0544633940dca551ad32a40
Quelldatensatz
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08653281B2

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