(5-Tert-butyl-2-methoxy-3-nitrophenyl)methanol → (3-Amino-5-tert-butyl-2-methoxyphenyl)methanol

HRID 243797Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 243797
[C:1]([C:5]1[CH:6]=[C:7]([N+:15]([O-])=O)[C:8]([O:13][CH3:14])=[C:9]([CH2:11][OH:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[NH2:15][C:7]1[C:8]([O:13][CH3:14])=[C:9]([CH2:11][OH:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=1

Komponenten

4

Edukt 1

HCID 58493934(5-Tert-butyl-2-methoxy-3-nitrophenyl)methanol

Produkt 1

HCID 58366895(3-Amino-5-tert-butyl-2-methoxyphenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of (5-tert-butyl-2-methoxy-3-nitrophenyl)methanol (0.250 g, 1.04 mmol) in ethyl acetate (10.4 mL), 10% palladium/activated charcoal (0.025 g) was added and the resulting mixture was stirred at room temperature under hydrogen atmosphere for 14 hours. After completion of the reaction, insoluble materials were filtered through a Celite pad, and the solvent was washed with ethyl acetate. The solvent of the filtrate was evaporated under reduced pressure to obtain 0.219 g (quantitative) of the crude product containing the captioned compound.

Aufarbeitung

  1. customAfter completion of the reaction, insoluble materials
  2. filtrationwere filtered through a Celite pad
  3. washthe solvent was washed with ethyl acetate
  4. customThe solvent of the filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b3b8e79bbc504cba9f693ebbff4c6a6a
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653304B2

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