p-Cyanobenzyl alcohol → N-Hydroxy-4-(hydroxymethyl)benzimidamide

HRID 243821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 243821
Cl.[NH2:2][OH:3].[OH:4][CH2:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.C(=O)([O-])O.[Na+]>CO>[OH:3][N:2]=[C:10]([C:9]1[CH:12]=[CH:13][C:6]([CH2:5][OH:4])=[CH:7][CH:8]=1)[NH2:11]

Komponenten

5

Edukt 3

HCID 160549p-Cyanobenzyl alcoholHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate

Produkt 1

HCID 53437716N-Hydroxy-4-(hydroxymethyl)benzimidamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of hydroxylamine hydrochloride (5.2 g), 4-(hydroxymethyl)benzonitrile (5.0 g), and sodium hydrogen carbonate (12.6 g) in methanol (50 mL) was heated to reflux for 20 hours. The reaction mixture was filtered through Celite (trade name). Thus, the filtrate was concentrated to thereby give the title compound having the following physical properties. The product was used for next reaction without further purification.

Aufarbeitung

  1. temperatureto reflux for 20 hours
  2. filtrationThe reaction mixture was filtered through Celite (trade name)
  3. concentrationThus, the filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-6fc5d554ea6a4ccb8735b339b659b6ee
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653305B2

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