Benzoic acid, 2-bromo-5-fluoro-, methyl ester → methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoate

HRID 243849

Reaktionsgleichung

Reaktionsgleichung von HRID 243849
Br[C:2]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[NH:13]1[C:17](B(O)O)=[CH:16][CH:15]=[N:14]1.C([O-])(O)=O.[Na+]>COCCOC.O>[F:12][C:9]1[CH:10]=[CH:11][C:2]([C:15]2[NH:14][N:13]=[CH:17][CH:16]=2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

Komponenten

6

Edukt 3

HCID 138875Benzoic acid, 2-bromo-5-fluoro-, methyl esterHCID 516892Sodium BicarbonateHCID 112519791H-Pyrazole-5-boronic acid

Produkt 1

HCID 67086678methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoateAusbeute 44,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 80711,2-DimethoxyethaneLösungsmittel

Reaktionsbedingungen

Temperatur
23 °C

Versuchsvorschrift

Methyl 2-bromo-5-fluorobenzoate (1.0 g, 4.2 mmol) and (1H-pyrazol-5-yl)boronic acid (485 mg, 4.6 mmol) were combined and dissolved in degassed DME (15 ml) then treated with NaHCO3 (706 mg, 8.4 mmol) in water and the reaction purged with bubbling N2 for 5 minutes. The reaction was treated with Pd(PPh3)4 (243 mg (0.2 mmol) and then purged with bubbling for 5 minutes in a sealed vessel and then heated to reflux for 2 h. The reaction mixture was cooled to 23° C., filtered, and solid rinsed with EtOAc. The organic layers were separated, dried and concentrated. Purification via FCC (ethyl acatate/hexanes, 0-30%) afforded methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoate (415 mg, 44%).

Aufarbeitung

  1. customthe reaction purged with bubbling N2 for 5 minutes
  2. additionThe reaction was treated with Pd(PPh3)4 (243 mg (0.2 mmol)
  3. custompurged
  4. customwith bubbling for 5 minutes in a sealed vessel
  5. temperatureheated
  6. temperatureto reflux for 2 h
  7. filtrationfiltered
  8. washsolid rinsed with EtOAc
  9. customThe organic layers were separated
  10. customdried
  11. concentrationconcentrated
  12. customPurification via FCC (ethyl acatate/hexanes, 0-30%)

Quellen und Nachweise

ORD-Eintrag
ord-bb7166fd3d904c0d84d22df8de72cb8c
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653263B2

Verknüpfte Notizen

Wird geladen…