1,2-Dimethoxyethane → methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoate

HRID 243877

Reaktionsgleichung

Reaktionsgleichung von HRID 243877
C[C:2]1[CH:10]=[CH:9][C:5](C([O-])=O)=[C:4]([F:11])[C:3]=1Br.[NH:13]1[C:17](B(O)O)=[CH:16][CH:15]=[N:14]1.[C:21]([O-:24])(O)=[O:22].[Na+].[CH3:26]OCCOC>O>[F:11][C:4]1[CH:3]=[CH:2][C:10]([C:17]2[NH:13][N:14]=[CH:15][CH:16]=2)=[C:9]([CH:5]=1)[C:21]([O:24][CH3:26])=[O:22]

Komponenten

6

Edukt 4

HCID 80711,2-DimethoxyethaneHCID 516892Sodium BicarbonateHCID 112519791H-Pyrazole-5-boronic acidHCID 53430578Methyl-2-fluoro-bromobenzoate

Produkt 1

HCID 67086678methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoateAusbeute 44 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
23 °C

Versuchsvorschrift

Methyl-2-fluoro-bromobenzoate (1.0 gram, 4.2 mmol) and (1H-pyrazol-5-yl)boronic acid (485 mg, 4.6 mmol) were combined and dissolved in degassed DME (15 mL) then treated with NaHCO3 (706 mg, 8.4 mmol) in water and the reaction purged with bubbling N2 for 5 minutes. The reaction was treated with Pd(PPh3)4 (243 mg (0.2 mmol) and then purged with bubbling for 5 minutes in a sealed vessel and then heated to reflux for 2 h. The reaction mixture was cooled to 23° C., filtered, and the solid was rinsed with EtOAc and the layers separated. The organic layers were combined, dried and concentrated. Chromatography (ethyl acatate/hexanes, 0-30%) gave methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoate (415 mg, 44%).

Aufarbeitung

  1. customthe reaction purged with bubbling N2 for 5 minutes
  2. additionThe reaction was treated with Pd(PPh3)4 (243 mg (0.2 mmol)
  3. custompurged
  4. customwith bubbling for 5 minutes in a sealed vessel
  5. temperatureheated
  6. temperatureto reflux for 2 h
  7. filtrationfiltered
  8. washthe solid was rinsed with EtOAc
  9. customthe layers separated
  10. customdried
  11. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-98d9399d610b413bab494ad585f968fc
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653263B2

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