Hydrochloric Acid → N-(5-bromo-2-methylpyridin-3-yl)methanesulfonamide

HRID 244682Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 244682
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Br:6][C:7]1[CH:8]=[C:9]([NH2:14])[C:10]([CH3:13])=[N:11][CH:12]=1.Cl.C(Cl)Cl>N1C=CC=CC=1>[Br:6][C:7]1[CH:8]=[C:9]([NH:14][S:2]([CH3:1])(=[O:4])=[O:3])[C:10]([CH3:13])=[N:11][CH:12]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 6344Dichloromethane2×HCID 31297Methanesulfonyl chlorideHCID 219640965-Bromo-2-methylpyridin-3-amine

Produkt 1

HCID 57545815N-(5-bromo-2-methylpyridin-3-yl)methanesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

Methanesulfonyl chloride (97 μl) was added dropwise to 5-bromo-2-methyl-3-pyridinamine (Chempacific) (200 mg) in pyridine (5 ml). The reaction was stirred at room temperature for 20 min before addition of 2M HCl (aq) (5 ml) and extraction into DCM. The DCM was passed through a hydrophobic frit then dried under a stream of nitrogen. The residue was dissolved in DCM and washed through an aminopropyl cartridge (preconditioned with DCM) with DCM to give title compound, 77 mg.

Aufarbeitung

  1. customthen dried under a stream of nitrogen
  2. dissolutionThe residue was dissolved in DCM
  3. washwashed through an aminopropyl cartridge (preconditioned with DCM) with DCM

Quellen und Nachweise

ORD-Eintrag
ord-afed0135a8b140f4b318f91a730a886e
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658635B2

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