Potassium Hydroxide → 2-Amino-5,6-bis(methoxymethyl)indane

HRID 244765

Reaktionsgleichung

Reaktionsgleichung von HRID 244765
[OH-].[K+].FC(F)(F)C([NH:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH2:20][O:21][CH3:22])=[C:13]([CH2:17][O:18][CH3:19])[CH:14]=2)[CH2:9]1)=O>O.CO>[NH2:7][CH:8]1[CH2:9][C:10]2[C:15](=[CH:14][C:13]([CH2:17][O:18][CH3:19])=[C:12]([CH2:20][O:21][CH3:22])[CH:11]=2)[CH2:16]1

Komponenten

5

Edukt 2

HCID 14797Potassium HydroxideHCID 224992202-(Trifluoroacetylamino)-5,6-bis(methoxymethyl)indane

Produkt 1

HCID 668228442-Amino-5,6-bis(methoxymethyl)indane

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of potassium hydroxide (150 mg, 2.60 mmol) in water (0.5 ml) is added to a solution of 2-(trifluoroacetylamino)-5,6-bis(methoxymethyl)indane (240 mg, 0.75 mmol) in methanol (3 mL) and the mixture is heated at reflux for 2.5 hours. The solvent was removed in vacuo and the residue is partitioned between aqueous sodium hydroxide (10 mL) and ethyl acetate (20 mL). The organic extract is dried (MgSO4) and the solvent is removed in vacuo to leave the product as a dark oil.

Aufarbeitung

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 2.5 hours
  3. customThe solvent was removed in vacuo
  4. customthe residue is partitioned between aqueous sodium hydroxide (10 mL) and ethyl acetate (20 mL)
  5. extractionThe organic extract
  6. dry with materialis dried (MgSO4)
  7. customthe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-46c1ada1240549c09f400d705806e93b
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658673B2

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