Aniline → 2-Anilino-2-methylpropiononitrile

HRID 244974Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 244974
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][C:9]([CH3:13])(O)[C:10]#[N:11]>C(OCC)(=O)C>[CH3:8][C:9]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([CH3:13])[C:10]#[N:11]

Komponenten

4

Edukt 2

HCID 6115AnilineHCID 6406Acetone Cyanohydrin

Produkt 1

HCID 751282-Anilino-2-methylpropiononitrileAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of aminobenzene (0.931 g, 10 mmol) and acetone cyanohydrin (2 ml) was heated to reflux and stirred for 20 h. After being cold to room temperature, the reaction mixture was poured into ethyl acetate (40 ml) and washed with cold water (2×30 ml). The organic layer was dried over MgSO4, concentrated under vacuum to dryness to yield 2-methyl-2-phenylaminopropanenitrile, 6a (1.51 g, 9.4 mmol, 94%) as slurry brown liquid.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux
  3. customAfter being cold to room temperature
  4. washwashed with cold water (2×30 ml)
  5. dry with materialThe organic layer was dried over MgSO4
  6. concentrationconcentrated under vacuum to dryness

Quellen und Nachweise

ORD-Eintrag
ord-e40861c200e4438ebcdee7cebb1aa4e4
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658681B2

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