2,2-Dimethoxypropane → HCID 67356722, Verbindung

HRID 245373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 245373
[F:1][C:2]1[C:9]([F:10])=[C:8]([F:11])C=C[C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]([O:17][CH3:18])(C)[CH3:15]>CCOCC.CC1C=CC(S(O)(=O)=O)=CC=1>[CH3:12][O:13][CH:14]([O:17][CH3:18])[C:15]1[CH:4]=[CH:3][C:2]([F:1])=[C:9]([F:10])[C:8]=1[F:11]

Komponenten

5

Edukt 2

HCID 64952,2-DimethoxypropaneHCID 5192262,3,4-Trifluorobenzaldehyde

Produkt 1

HCID 67356722HCID 67356722, VerbindungAusbeute 71,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6101p-Toluenesulfonic acidKatalysatorHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 2,3,4-trifluorobenzaldehyde (25 g, 156.16 mmol), 2,2-dimethoxypropane (58.1 ml, 468.48 mmol), and 4-methylbenzenesulfonic acid (0.269 g, 1.56 mmol) was stirred at room temperature overnight. The reaction mixture diluted with ether and washed successively with aq. sodium bicarbonate solution, water, and brine. The organic layer dried over sodium sulfate and concentrated. The residue wasdistilled under high vacuum to give the title compound (23.07 g, 71.7%).

Aufarbeitung

  1. washwashed successively with aq. sodium bicarbonate solution, water, and brine
  2. dry with materialThe organic layer dried over sodium sulfate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ac8141f9b0d146089b64d53c6e1b46c8
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658641B2

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