Water → HCID 178502113, Verbindung

HRID 245761Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 245761
[Br:1][C:2]1[N:3]=[C:4]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][NH2:19])[CH2:14][CH2:13]2)[N:5]2[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]=12.C(N(CC)CC)C.[C:27](Cl)(=[O:30])[O:28][CH3:29].O>ClCCl>[CH3:29][O:28][C:27](=[O:30])[NH:19][CH2:18][C@H:15]1[CH2:16][CH2:17][C@H:12]([C:4]2[N:5]3[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]3=[C:2]([Br:1])[N:3]=2)[CH2:13][CH2:14]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 178432907HCID 178432907, Verbindung

Produkt 1

HCID 178502113HCID 178502113, VerbindungAusbeute 54,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To ((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methanamine (0.464 mmol, 150 mg) in dichloromethane (5 ml) at 0° C. were added triethylamine (0.464 mmol, 64.7 μl) and methyl carbonochloridate (0.505 mmol, 39 μl). After stirring at room temperature for one hour water was added. The organic layer separated, dried (Na2SO4) and concentrated in vacuo to give methyl((trans)-4-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)cyclohexyl)methylcarbamate (97 mg).

Aufarbeitung

  1. additionwas added
  2. customThe organic layer separated
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5361bae56cb24c0cb4083e6fbfc498ac
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08658794B2

Notizen zur Reaktion

Wird geladen…