Acetic Anhydride → (3-chlorophenyl)methyl Acetate

HRID 247727

Reaktionsgleichung

Reaktionsgleichung von HRID 247727
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].[C:10](OC(=O)C)(=[O:12])[CH3:11]>C1C=CC=CC=1>[C:10]([O:6][CH2:5][C:4]1[CH:7]=[CH:8][CH:9]=[C:2]([Cl:1])[CH:3]=1)(=[O:12])[CH3:11]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 701173-Chlorobenzyl alcohol

Produkt 1

HCID 11217649(3-chlorophenyl)methyl AcetateAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Into a solution of 84.4 g. (0.592 mole) of 3-chlorobenzyl alcohol in 40 cm3. of benzene 61.5 g. (0.6 mole) of acetic acid anhydride are dropped during 15 minutes while boiling. The reaction mixture is refluxed with 100 cm3. of benzene and washed with 100 cm3. of water thoroughly. The organic phase is separated and evaporated. 105.2 g. of 3-chlorobenzyl acetate are obtained which is suitable to ether-formation. nD20 : 1.5226, yield 96%.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed with 100 cm3
  2. washof benzene and washed with 100 cm3
  3. customThe organic phase is separated
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-0454e46b42c644bf8206535480ccf04b
Quelldatensatz
uspto-grants-1987_11
Patentnummer
US04709081

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