Potassium Carbonate → HCID 54095197, Verbindung

HRID 248012

Reaktionsgleichung

Reaktionsgleichung von HRID 248012
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([OH:11])[CH:5]=1.I[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[C:6]([O:11][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[CH:5]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 202741-IodoheptaneHCID 287064Methyl 3,4-Dihydroxybenzoate

Produkt 1

HCID 54095197HCID 54095197, VerbindungAusbeute 198,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

A mixture of 25 g of product from Example 102, 72.3 g of 1-iodoheptane, 61.65 g of potassium carbonate and 500 ml of 2-butanone is heated at reflux temperature for 44 hours. The cooled reaction mixture is filtered and concentrated in vacuo. The oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane) to give 53.7 g of the desired product.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux temperature for 44 hours
  3. customThe cooled reaction mixture
  4. filtrationis filtered
  5. concentrationconcentrated in vacuo
  6. customThe oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-6aa4604a96724dc7be7271e866ed0eb3
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05208247

Verknüpfte Notizen

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