Ethanol → HCID 19015379, Verbindung

HRID 248028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 248028
C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[C:6]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:5]=1.[OH-].[K+].CO.C(O)C>O>[CH2:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:25])=[O:2])=[CH:5][C:6]=1[C:21]([CH3:22])([CH3:24])[CH3:23])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 887MethanolHCID 14797Potassium HydroxideHCID 539263074-(Decyloxy)-3-(1,1-dimethylethyl)benzoic acid methyl ester

Produkt 1

HCID 19015379HCID 19015379, VerbindungAusbeute 90,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 15.0 g of product from Example 130, 7.24 g of potassium hydroxide, 100 ml methyl alcohol, 40 ml ethyl alcohol and 10 ml of water is heated at reflux temperature for 18 hours. The reaction is cooled to room temperature, made acidic to pH 2, concentrated in vacuo, swirled with water and the solid collected. The solid residue is washed with water and dried in a vacuum oven to give 13 g of the desired product as colorless needles.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux temperature for 18 hours
  3. concentrationconcentrated in vacuo
  4. customthe solid collected
  5. washThe solid residue is washed with water
  6. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-4b8c05b220b94513880905fce8c955b2
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05208247

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