Isobutylbenzene → 1-(4-(2-Methylpropyl)phenyl)-1-propanone

HRID 249146

Reaktionsgleichung

Reaktionsgleichung von HRID 249146
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[Cl-].[Al+3].[Cl-].[Cl-].[CH2:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH:11]([CH3:13])[CH3:12]>ClCCl>[CH2:10]([C:14]1[CH:19]=[CH:18][C:17]([C:1](=[O:4])[CH2:2][CH3:3])=[CH:16][CH:15]=1)[CH:11]([CH3:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 10870IsobutylbenzeneHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 1088341-(4-(2-Methylpropyl)phenyl)-1-propanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Propionyl chloride (13.0 ml) was added to a suspension of aluminum chloride (20.0 g) in dichloromethane (200 ml) at 0° C. After the mixture was stirred at 0° C. for 1 hour, isobutylbenzene (23.6 ml) was added to the mixture. The mixture was stirred at 0° C. for 2 hours and poured into ice water. The organic layer was washed with water, dried over magnesium sulfate and evaporated. The residual oil was distilled under reduced pressure to give 4'-isobutylpropiophenone as a colourless oil (24.4 g).

Aufarbeitung

  1. stirringThe mixture was stirred at 0° C. for 2 hours
  2. washThe organic layer was washed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. distillationThe residual oil was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-dd0074dde56f45898c7b4046bbf60793
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05212320

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