2-Methylanisole → 4-Bromo-1-methoxy-2-methylbenzene

HRID 249279

Reaktionsgleichung

Reaktionsgleichung von HRID 249279
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:10][C:6]1[CH:5]=[CH:4][C:3]([O:8][CH3:9])=[C:2]([CH3:1])[CH:7]=1

Komponenten

5

Edukt 2

HCID 336372-MethylanisoleHCID 67184N-bromobutanimide

Produkt 1

HCID 6083154-Bromo-1-methoxy-2-methylbenzeneAusbeute 47,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7187Benzoyl PeroxideKatalysatorHCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

A solution of 24 g of 2-methylanisole, 35 g of N-bromosuccinimide and 1.24 g of dibenzoyl peroxide in 150 ml of carbon tetrachloride was heated to boiling under reflux for 12 hours. After cooling the solution was filtered and the filtrate is evaporated. The residue was recrystallized from hexane. There were obtained 18.6 g (47%) of 4-bromo-2-methylanisole as a colorless solid; m.p. 66°-68°.

Aufarbeitung

  1. temperatureunder reflux for 12 hours
  2. temperatureAfter cooling the solution
  3. filtrationwas filtered
  4. customthe filtrate is evaporated
  5. customThe residue was recrystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-e726e1f3800646a79b1e16dd269c2994
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05214046

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