4-Nitrobenzenesulfonyl chloride → N,N-dimethyl-4-nitrobenzenesulfonamide

HRID 24951

Reaktionsgleichung

Reaktionsgleichung von HRID 24951
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[CH3:15][NH:16][CH3:17].C(N(C(C)C)C)(C)C>ClCCl>[CH3:15][N:16]([CH3:17])[S:10]([C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)(=[O:12])=[O:11]

Komponenten

5

Edukt 3

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 10473Dimethylamine, hydrochlorideHCID 547370N,N-Diisopropylmethylamine

Produkt 1

HCID 2747580N,N-dimethyl-4-nitrobenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4.43 g (20 mmol) of 4-nitrobenzenesulphonic acid chloride are added dropwise at 0° C. to a solution of 2.45 g (30 mmol) of dimethylamine-hydrochloride and 6.46 g (50 mmol) of N,N-diisopropyl-N-methylamine in 30 ml of dichloromethane. The mixture is stirred for 18 hours at ambient temperature. Then the reaction solution is washed with water and dilute hydrochloric acid, dried over magnesium sulphate and evaporated to dryness.

Aufarbeitung

  1. washThen the reaction solution is washed with water and dilute hydrochloric acid
  2. dry with materialdried over magnesium sulphate
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-fa275b5c963c420186aa69e2eb377b96
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855710B2

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