Methyl isothiocyanate → N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea

HRID 249510

Reaktionsgleichung

Reaktionsgleichung von HRID 249510
[CH2:1]([NH:3][CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)[CH3:2].[CH3:11][N:12]=[C:13]=[S:14]>C(OCC)C>[CH3:11][NH:12][C:13]([N:3]([CH2:1][CH3:2])[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)=[S:14]

Komponenten

4

Edukt 2

HCID 11167Methyl isothiocyanateHCID 4716480Ethyl[(pyridin-3-yl)methyl]amine

Produkt 1

HCID 22450434N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thioureaAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

In 50 ml of ethyl ether was dissolved 2.4 g of N-ethyl-N-(3-pyridylmethyl)amine followed by addition of 1.3 g of methyl isothiocyanate. The mixture was stirred at room temperature (25° C.) for 1 hour. The resulting precipitate was collected by filtration, washed with a small amount of ethyl ether and dried to give 3.7 g of N-methyl-N'-ethyl-N'-(3-pyridylmethyl)thiourea as white prisms.

Aufarbeitung

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with a small amount of ethyl ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-44541d504266468eb6785c420de3fa6e
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05214152

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