Hydrochloric Acid → 1-Chloro-4-hydroxyisoquinoline-3-carboxylic acid

HRID 250368

Reaktionsgleichung

Reaktionsgleichung von HRID 250368
C([O:5][C:6]([C:8]1[N:9]=[C:10]([Cl:19])[C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7])CCC.[OH-].[Na+].O.Cl>C(O)C>[Cl:19][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([OH:18])=[C:8]([C:6]([OH:7])=[O:5])[N:9]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 860145021-Chloro-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester

Produkt 1

HCID 110205201-Chloro-4-hydroxyisoquinoline-3-carboxylic acidAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 9.23 g of 1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester (33 mmol), 90 ml of 2.5 N aqueous sodium hydroxide solution, water (20 ml) and ethanol (110 ml) was refluxed with stirring for 2 h. Then the pH of the mixture was adjusted to 2 by the addition of concentrated aqueous hydrochloric acid. During the addition the temperature of the mixture was kept at 20° C. by cooling with an ice bath. Stirring was then continued for 1 h before the solid component was separated by vacuum filtration. The filter cake was washed with water and dried in vacuo at 85° C. to give a white powder. 6.64 g of the title compound were obtained; MS-(+)-ion: M+1=224.1.

Aufarbeitung

  1. temperaturewas refluxed
  2. additionDuring the addition the temperature of the mixture
  3. customwas kept at 20° C.
  4. temperatureby cooling with an ice bath
  5. stirringStirring
  6. waitwas then continued for 1 h before the solid component
  7. customwas separated by vacuum filtration
  8. washThe filter cake was washed with water
  9. customdried in vacuo at 85° C.
  10. customto give a white powder

Quellen und Nachweise

ORD-Eintrag
ord-2d72809615874210b7a4902bca34b388
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07863292B2

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