HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isoquinoline-1-carbaldehyde → {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-isoquinolin-1-ylmethyl-amino]-butyl}-methyl-carbamic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isoquinoline-1-carbaldehyde | HCID 265306 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester | HCID 58997083 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-isoquinolin-1-ylmethyl-amino]-butyl}-methyl-carbamic acid tert-butyl ester | HCID 67273128 | — |
Reaktionsschritte
Using General Procedure B: Reaction of {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-methyl-carbamic acid tert-butyl ester and 1-isoquinoline-carbaldehyde with NaBH(OAc)3 in CH2Cl2 gave {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-isoquinolin-1-ylmethyl-amino]-butyl}-methyl-carbamic acid tert-butyl ester as a yellow oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07863293B2 |
| Quelldatensatz | uspto-grants-2011_01 |
| ORD ID | ord-a50f68fe49214ff8a95723cce38b7aff |
| Quellennotiz | uspto-grants-2011_01 |