6-nitro-3,4-dihydro-2H-1,4-benzoxazine → 3,4-Dihydro-2H-1,4-benzoxazin-6-amine

HRID 25146Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 25146
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][CH2:11][CH2:10][NH:9][C:8]=2[CH:13]=1)([O-])=O>CO.[Pd]>[O:12]1[C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:13][C:8]=2[NH:9][CH2:10][CH2:11]1

Komponenten

4

Edukt 1

HCID 70622256-nitro-3,4-dihydro-2H-1,4-benzoxazine

Produkt 1

HCID 113441023,4-Dihydro-2H-1,4-benzoxazin-6-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 6-nitro-3,4-dihydro-2H-benzo[1,4]oxazine (1.8 g, 10.0 mmol) in methanol (150 mL) was hydrogenated on a Parr hydrogenator for 6 hours with 10% palladium on carbon (1.06 g) as a catalyst. The reaction mixture was filtered through Celite to remove the catalyst and the Celite rinsed with methanol. The filtrate was evaporated under vacuum to yield 3,4-dihydro-2H-benzo[1,4]oxazin-6-yl amine as a solid product.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. customto remove the catalyst
  3. washthe Celite rinsed with methanol
  4. customThe filtrate was evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d811f28b55294d70b508b3aedf4b2ef0
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858621B2

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