3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile

HRID 251806

Reaktionsgleichung

Reaktionsgleichung von HRID 251806
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1>C1COCC1.CO.[Pd]>[N:10]1[C:9]([C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[C:14]#[N:15])=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[N:7]2

Komponenten

4

Edukt 1

HCID 468355643-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile

Produkt 1

HCID 534394773-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

2.5 mg 10% Pd-C were added to the solution of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (50 mg, 0.2 mmol) in THF/MeOH 25 ml. The reaction mixture was stirred vigorously at room temperature for 4 h under hydrogen and the Pd—C was then removed. The filtrate was concentrated in vacuo to give the 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile as a yellow-white solid.

Aufarbeitung

  1. customthe Pd—C was then removed
  2. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ab15fbc426654cfabef2405f47f2265e
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07868001B2

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