Pyrazole → N,N-dimethyl-1H-pyrazole-1-sulfonamide

HRID 251912

Reaktionsgleichung

Reaktionsgleichung von HRID 251912
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.C1(C)C=CC=CC=1.[CH3:13][N:14]([CH3:19])[S:15](Cl)(=[O:17])=[O:16]>C(N(CC)CC)C>[CH3:13][N:14]([CH3:19])[S:15]([N:1]1[CH:5]=[CH:4][CH:3]=[N:2]1)(=[O:17])=[O:16]

Komponenten

5

Edukt 3

HCID 1048PyrazoleHCID 1140TolueneHCID 83372Dimethylsulphamoyl chloride

Produkt 1

HCID 10954038N,N-dimethyl-1H-pyrazole-1-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a mixture of 15 g of pyrazole and 200 ml of toluene was added dropwise 23.7 ml of dimethylsulfamoyl chloride at room temperature. Then, 40 ml of triethylamine was added to the mixture, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 17.6 g of N,N-dimethyl-1H-pyrazole-1-sulfonamide of the formula:

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-14e014218f524dfa98603c57aeceaf44
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07867949B2

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