4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 252430Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 252430
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

Produkt 1

HCID 45247074-BROMO-4'-SULFOBIPHENYLAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A 500 mL round-bottom-flask equipped with an addition funnel, stirring bar, and gas inlet was charged with 4-bromo-biphenyl (50 g, 0.215 mol) and chloroform (200 mL) then purged with nitrogen. Chlorosulfonic acid (18 mL, 0.27 mol) was added dropwise to the solution from the addition funnel then stirred for 1 hour. The resulting precipitate was collected by vacuum filtration, washed with cold chloroform, and dried under vacuum to give 61.97 g of 4′-bromo-biphenyl-4-sulfonic acid (92% yield).

Aufarbeitung

  1. customA 500 mL round-bottom-flask equipped with an addition funnel
  2. customthen purged with nitrogen
  3. stirringthen stirred for 1 hour
  4. filtrationThe resulting precipitate was collected by vacuum filtration
  5. washwashed with cold chloroform
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-8d95b9619dcc40e9810898c9e6d4841e
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07868086B2

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