1-(6-Nitroindolin-1-yl)ethanone → 1-Acetyl-6-aminoindoline

HRID 252570

Reaktionsgleichung

Reaktionsgleichung von HRID 252570
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N+:13]([O-])=O)[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>CCOC(C)=O.[Pd]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([NH2:13])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 2585661-(6-Nitroindolin-1-yl)ethanone

Produkt 1

HCID 2585641-Acetyl-6-aminoindolineAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1-Acetyl-6-nitroindoline (3.8 g, 18.3 mmol) is suspended in EtOAc (200 mL). Pd/C (650 mg, 10%) is added, and the mixture is hydrogenated at 40-55 p.si.i. for 2 hours. The mixture is then filtered through celite. The filtrate is concentrated, and the residue is triturated with ether to yield 1-acetyl-6-aminoindoline (3.18 g, 99%) as an orange solid.

Aufarbeitung

  1. filtrationThe mixture is then filtered through celite
  2. concentrationThe filtrate is concentrated
  3. customthe residue is triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-016ce40fa92c430bafabec3f3c9e9893
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07868037B2

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