Methyl 4-(aminomethyl)benzoate hydrochloride → Methyl 4-(guanidinomethyl)benzoate

The mixture of 4-Aminomethyl-benzoic acid methyl ester HCl (15.7 g, 77.8 mmol) in DMF (85.6 mL) and DIPEA (29.5 mL, 171.2 mmol; was stirred at rt for 10 min. Pyrazole-1-carboxamidine HCl (12.55 g, 85.6 mmol) was added to the reaction mixture and then stirred at rt for 4 h to give clear solution. The reaction mixture was evaporated to dryness under vacuum. Saturated NaHCO3 solution (35 mL) was added to give nice suspension. The suspension was filtered and the filter cake was washed with cold water. The mother liquid was evaporated to dryness and then filtered. The two solids were combined and re-suspended over distilled H2O (50 ml). The filter cake was then washed with minimum quantities of cold H2O and ether to give 12.32 g white crystallin a solid intermediate 1 (77% yield, M+1: 208 on MS).

1. stirringstirred at rt for 4 h
2. customto give clear solution
3. customThe reaction mixture was evaporated to dryness under vacuum
4. additionSaturated NaHCO3 solution (35 mL) was added
5. customto give nice suspension
6. filtrationThe suspension was filtered
7. washthe filter cake was washed with cold water
8. customThe mother liquid was evaporated to dryness
9. filtrationfiltered
10. distillationover distilled H2O (50 ml)
11. washThe filter cake was then washed with minimum quantities of cold H2O and ether

ORD-Eintrag

ord-9a908751e1664b04a8e314912de2061e

Quelldatensatz

uspto-grants-2011_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07868204B2