Morpholine → 2-Methyl-4-chloro-6-morpholino-pyridine

HRID 252983

Reaktionsgleichung

Reaktionsgleichung von HRID 252983
[CH3:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>ClCCl>[CH3:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:3]=1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 119590832,4-Dichloro-6-methylpyridine

Produkt 1

HCID 575505222-Methyl-4-chloro-6-morpholino-pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

2-Methyl-4,6-dichloropyridine (256 mmol) is dissolved in dichloromethane (200 mL) and chilled to −78° C. in an inert atmosphere. Morpholine (550 mol) dissolved in dichloromethane (100 mL) is added slowly. The reaction is allowed to warm to room temperature while stirring overnight. The organic layer is washed with saturated ammonium chloride (2×100 mL), dried with sodium sulfate, and evaporated to give 2-methyl-4-chloro-6-morpholino-pyridine.

Aufarbeitung

  1. additionis added slowly
  2. temperatureto warm to room temperature
  3. washThe organic layer is washed with saturated ammonium chloride (2×100 mL)
  4. dry with materialdried with sodium sulfate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f6527866ffd046748a51042fcc0e358d
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07872005B2

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