Hydrochloric Acid → HCID 57434496, Verbindung

HRID 253334

Reaktionsgleichung

Reaktionsgleichung von HRID 253334
[ClH:1].C(O)C.O[N:6]=[C:7]([C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[C:8]([O:10][CH2:11][CH3:12])=[O:9]>[Pd]>[ClH:1].[NH2:6][CH:7]([C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178472908HCID 178472908, Verbindung

Produkt 1

HCID 57434496HCID 57434496, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumLösungsmittel

Versuchsvorschrift

10 g of HCl are introduced into 200 ml of ethanol. 46 g of ethyl 2-hydroxyimino-4-methyl-3-oxopentanoate are dissolved in this mixture, 5 g of Pd (10% on carbon) are added and the mixture is stirred under an atmosphere of hydrogen (5 bar) for 8 hours. The reaction mixture is filtered through Celite and the solvent is removed under reduced pressure. This gives 45 g of ethyl 2-amino-4-methyl-3-oxopentanoate hydrochloride as a white solid. C8H15NO3*HCl (209.5), MS (ESI)=188 (M+H+).

Aufarbeitung

  1. additionare added
  2. filtrationThe reaction mixture is filtered through Celite
  3. customthe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8e2d217522d847769669ae1246a0eb9c
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07872034B2

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