Hydrazine hydrate (1:1) → HCID 11260812, Verbindung

HRID 253513Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 253513
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:26][CH:25]=2)=[CH:20][C:19]=1[C:35]1[CH:44]=[CH:43][C:42]2[C:41]([CH3:46])([CH3:45])[CH2:40][CH2:39][C:38]([CH3:48])([CH3:47])[C:37]=2[CH:36]=1.O.NN>C(O)C>[NH2:3][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:26][CH:25]=2)=[CH:20][C:19]=1[C:35]1[CH:44]=[CH:43][C:42]2[C:41]([CH3:46])([CH3:45])[CH2:40][CH2:39][C:38]([CH3:47])([CH3:48])[C:37]=2[CH:36]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 66856502Ethyl 4'-[5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentyloxy]-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate

Produkt 1

HCID 11260812HCID 11260812, VerbindungAusbeute 46,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

In a manner similar to that of Example 17b, by reaction of 760 mg (1.18 mmol) of ethyl 4′-[5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentyloxy]-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate with 230 μl (4.72 mmol) of hydrazine monohydrate in 50 ml of ethanol. 280 mg of ethyl 4′-(5-aminopentyloxy)-3′-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphth-2-yl)biphenyl-4-carboxylate are obtained in the form of a whitish solid (yield=46%).

Quellen und Nachweise

ORD-Eintrag
ord-54072d726f604eb4a371af407c7944f6
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07872026B2

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