N-(5-nitropyrimidin-2-yl)acetamide → N-(5-aminopyrimidin-2-yl)acetamide

HRID 253699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 253699
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[N:8][CH:9]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[N:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 45071770N-(5-nitropyrimidin-2-yl)acetamide

Produkt 1

HCID 20387481N-(5-aminopyrimidin-2-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To N-(5-nitropyrimidin-2-yl)acetamide (0.54 g, 3.0 mmol) suspended in EtOH (20 mL) under N2 was added palladium, 10 wt. % on activated carbon (0.32 g, 0.3 mmol). The reaction mixture was hydrogenated under 1 atm of H2 at RT for 2 h and then filtered through a pad of celite and washed with MeOH. The filtrate was concentrated to give N-(5-aminopyrimidin-2-yl)acetamide as a light-yellow solid. MS (ESI, pos. ion) m/z: 153 (M+1).

Aufarbeitung

  1. filtrationfiltered through a pad of celite
  2. washwashed with MeOH
  3. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-fd1f2a3caa724de3b8536cf547ac63e8
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07872128B2

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