Thiophosgene → 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl isothiocyanate
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6]([C:12]1[CH:13]=[CH:14][C:15]([O:19][CH3:20])=[C:16]([NH2:18])[CH:17]=1)=[CH:5]2.[C:21](Cl)(Cl)=[S:22]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6]([C:12]1[CH:13]=[CH:14][C:15]([O:19][CH3:20])=[C:16]([N:18]=[C:21]=[S:22])[CH:17]=1)=[CH:5]2Komponenten
3
Versuchsvorschrift
The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine (5.48 g, 20 mmol) was reacted with thiophosgene (1.9 mL, 25 mmol) according to the procedure for Example 26, Step A to give the product as a greenish tan solid (5.40 g).
Quellen und Nachweise
- ORD-Eintrag
- ord-dc5cf2e30cef4cf492296d8aa530e53a
- Quelldatensatz
- uspto-grants-2005_02