4-Methoxy-2-nitrobenzoic acid → 2-Amino-4-methoxybenzoic acid

HRID 255276

Reaktionsgleichung

Reaktionsgleichung von HRID 255276
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([N+:12]([O-])=O)[CH:4]=1>[Pd].CO>[NH2:12][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 1

HCID 2886574-Methoxy-2-nitrobenzoic acid

Produkt 1

HCID 3510102-Amino-4-methoxybenzoic acidAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-Methoxy-2-nitrobenzoic acid (3 g, 16.4 mmol) was hydrogenated over palladium on carbon (10%, 300 mg) in methanol (80 mL) at room temperature and normal pressure for 18 hours. The reaction mixture was filtered through celite and concentrated to dryness under reduce pressure to give 2.50 g (100%) of the product as a colorless solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite and
  2. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-f8f4666ef20642c2a03ae86bb6637376
Quelldatensatz
uspto-grants-2011_01
Patentnummer
US07875715B2

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