Ethyl 6-hydroxy-7-(prop-2-en-1-yl)-1H-indole-2-carboxylate → HCID 20183534, Verbindung

HRID 255508Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 255508
[OH:1][C:2]1[C:10]([CH2:11][CH:12]=[CH2:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[NH:8]2)=[CH:4][CH:3]=1>C(O)C.[Pd]>[OH:1][C:2]1[C:10]([CH2:11][CH2:12][CH3:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[NH:8]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 13203765Ethyl 6-hydroxy-7-(prop-2-en-1-yl)-1H-indole-2-carboxylate

Produkt 1

HCID 20183534HCID 20183534, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The product of step b) was dissolved in dry ethanol (350 ml), treated with 10% Pd/C (0.3 g) and hydrogenated at 35 psi at room temperature until H2 uptake ceased (1.5 hours). The catalyst was filtered off and the filtrate evaporated to dryness.

Aufarbeitung

  1. custom(1.5 hours)
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-15372c7080454dc689a6f0ecb4b3b457
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04698345

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