Acetic Acid → HCID 3021979, Verbindung

Reaktionsgleichung

[OH-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:19]([CH:20]=[CH:21][C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:18][C:17](=[O:28])[C:12]([C:13]([O:15]C)=[O:14])=[CH:11]2)=[CH:6][CH:5]=1.C(O)(=O)C>C(O)C>[F:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:19]([CH:20]=[CH:21][C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:18][C:17](=[O:28])[C:12]([C:13]([OH:15])=[O:14])=[CH:11]2)=[CH:8][CH:9]=1

Komponenten

Versuchsvorschrift

In a mixture of 9 ml of ethanol and 9 ml of a 10% by weight aqueous sodium hydroxide solution was suspended 0.45 g of methyl 1-(4-fluorophenyl)-6-[2-(pyridin-3-yl)ethenyl]-4-oxo-1,4-dihydronicotinate and the suspension was subjected to reaction at room temperature for 30 minutes. After completion of the reaction, the reaction mixture was adjusted to a pH of 6.0 with acetic acid, and the precipitated crystals were collected by filtration and dried to obtain 0.357 g of 1-(4-fluorophenyl)-6-[2-(pyridin-3-yl)ethenyl]-4-oxo-1,4-dihydronicotinic acid having a melting point of 250° C. or more.