Trifluoroacetic acid → HCID 178464450, Verbindung

HRID 25598

Reaktionsgleichung

Reaktionsgleichung von HRID 25598
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.Cl[C:27]([O:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][CH:31]=1)=[O:28].[CH2:40]([NH:42][CH2:43][CH2:44][OH:45])[CH3:41]>>[F:37][C:36]([F:39])([F:38])[C:33]1[CH:34]=[CH:35][C:30]([O:29][C:27](=[O:28])[N:2]([C@H:3]2[CH2:4][CH2:5][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:42]([CH2:40][CH3:41])[CH2:43][CH2:44][OH:45])[CH2:7][CH2:8]2)[CH3:1])=[CH:31][CH:32]=1

Komponenten

5

Edukt 4

HCID 6422Trifluoroacetic acidHCID 80722-(Ethylamino)ethanolHCID 159175974-(Trifluoromethyl)phenyl carbonochloridateHCID 178484796HCID 178484796, Verbindung

Produkt 1

HCID 178464450HCID 178464450, Verbindung

Versuchsvorschrift

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-trifluoromethyl-phenyl chloroformate were reacted, followed by treatment with 2-ethylamino-ethanol to yield trans-(4-{5-[Ethyl-(2-hydroxy-ethyl)-amino]-pentyl}-cyclohexyl)-methyl-carbamic acid 4-trifluoromethyl-phenyl ester, MS: 459 (MH+).

Quellen und Nachweise

ORD-Eintrag
ord-f2334a93a3a0489792031f1466a1defd
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06858651B2

Verknüpfte Notizen

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