Phosphorus pentachloride → 2-t-Butoxycarbonylamino-1-chloro-1-(2-thienyl)ethane

HRID 256060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 256060
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)O)=[O:7])([CH3:4])([CH3:3])[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:18]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([Cl:18])[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 24819Phosphorus pentachlorideHCID 13854069Carbamic acid, [2-hydroxy-2-(2-thienyl)ethyl]-, 1,1-dimethylethyl ester

Produkt 1

HCID 138540702-t-Butoxycarbonylamino-1-chloro-1-(2-thienyl)ethane

Versuchsvorschrift

Following the procedure described in Example 42(b), 15 g of 2-t-butoxycarbonylamino-1-(2-thienyl)ethanol were chlorinated using phosphorus pentachloride to afford 13.6 g of the title product as crystals melting at 40°-43° C. This substance was used for next step without purification because it was decomposed by silica gel column chromatography.

Quellen und Nachweise

ORD-Eintrag
ord-d545e62841c642bca6e98f9aa3aecc6d
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04699905

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