Water → 3-(3-(5-Hexenyloxy)-1,2,5-thiadiazol-4-yl)pyridine

HRID 256973

Reaktionsgleichung

Reaktionsgleichung von HRID 256973
[CH2:1]([OH:7])[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6].[H-].[Na+].Cl[C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1.O>O1CCCC1>[CH2:1]([O:7][C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1)[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6]

Komponenten

6

Edukt 4

HCID 962WaterHCID 24758Sodium hydrideHCID 699635-Hexen-1-olHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

Produkt 1

HCID 107065433-(3-(5-Hexenyloxy)-1,2,5-thiadiazol-4-yl)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a solution of 5-hexen-1-ol (900 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

Aufarbeitung

  1. extractionthe mixture was extracted with ether
  2. dry with materialThe ether phase was dried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-de2db69a59f3442298824da9564c774f
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05260311

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