HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Acid → 4-(N-methyl-N-(2-phenylethyl)amino)-1-(4-nitrophenyl)piperidine fumarate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | N-Methylbenzeneethanamine | HCID 11503 | — |
| Edukt | Fumaric Acid | HCID 444972 | — |
| Edukt | 1-(4-Nitrophenyl)piperidin-4-one | HCID 3842562 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | Fumarate | HCID 5460307 | — |
| Produkt | 4-(N-methyl-N-(2-phenylethyl)amino)-1-(4-nitrophenyl)piperidine fumarate | HCID 19784377 | — |
Reaktionsschritte
2.5 g (11.4 mmol) of 1-(4-nitrophenyl)-4-piperidone, 1.5 g (11.4 mmol) of N-methyl-N-(2-phenylethyl)amine, 0.7 g (11.4 mmol) of acetic acid and 0.7 g (11.4 mmol) of sodium cyanoborohydride were reacted in a similar manner to Example 1. The product was converted into the fumarate with fumaric acid in a conventional manner. 2.8 g of 4-(N-methyl-N-(2-phenylethyl)amino)-1-(4-nitrophenyl)piperidine fumarate were obtained. Melting point 201°-202° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05260318 |
| Quelldatensatz | uspto-grants-1993_11 |
| ORD ID | ord-0e21e3335dc744fabbd6631370a16d32 |
| Quellennotiz | uspto-grants-1993_11 |