2,6-Lutidine → Benzo[d][1,2,3]thiadiazole-7-carbaldehyde

HRID 257131

Reaktionsgleichung

Reaktionsgleichung von HRID 257131
[S:1]1[C:5]2[C:6]([C:10](Cl)=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1.N1C(C)=CC=CC=1C>C(OCC)(=O)C.O1CCCC1.[Pd]>[S:1]1[C:5]2[C:6]([CH:10]=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[N:2]1

Komponenten

6

Edukt 2

HCID 79372,6-LutidineHCID 183776071,2,3-Benzothiadiazole-7-carbonyl chloride

Produkt 1

HCID 14835681Benzo[d][1,2,3]thiadiazole-7-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysator2×HCID 8028TetrahydrofuranLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

99 g of benzo-1,2,3-thiadiazole-7-carboxylic acid chloride are dissolved in 1.2 l of ethyl acetate, the mixture is treated at 0°-5° C. with a solution of 58.7 g of 2,6-lutidine in 200 ml of tetrahydrofuran as well as 33 g of palladium/charcoal catalyst (5% Pd), and hydrogenated under low pressure (104Pa) with a further addition of a total of 57 g of palladium/charcoal catalyst and 500 ml of tetrahydrofuran in 5 portions. The catalyst is subsequently removed by filtration and washed with tetrahydrofuran, and the filtrate is evaporated. The residue is purified on silica gel (CH2Cl2) and gives the title compound of m.p. 134°-136° C.

Aufarbeitung

  1. customThe catalyst is subsequently removed by filtration
  2. washwashed with tetrahydrofuran
  3. customthe filtrate is evaporated
  4. customThe residue is purified on silica gel (CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-d433502191674bf18c619faa0ceef992
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05260423

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