Isopropylamine → HCID 15679400, Verbindung

HRID 257408Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 257408
[CH:1]([NH2:4])([CH3:3])[CH3:2].[CH3:5][C:6]1[CH:7]=[C:8]2[C:15](=[O:16])[O:14][C:12](=[O:13])[C:9]2=[N:10][CH:11]=1>C(Cl)Cl>[CH:1]([NH:4][C:12]([C:9]1[C:8]([C:15]([OH:16])=[O:14])=[CH:7][C:6]([CH3:5])=[CH:11][N:10]=1)=[O:13])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 11182791112110-17-5

Produkt 1

HCID 15679400HCID 15679400, VerbindungAusbeute 91,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3.25 g of isopropylamine are added to 8.1 g of 5-methylpyridine-2,3-dicarboxylic anhydride in 50 ml of methylene chloride at from 20° to 30° C. while stirring, and the stirred mixture is refluxed for 3 hours. The reaction mixture is evaporated down under reduced pressure and the residue is stirred in a 1:1:1 mixture of ether, methyl tert-butyl ether and petroleum ether. Filtration under suction and drying give 10.1 g of the title compound as colorless crystals of melting point 95°-105° C.

Aufarbeitung

  1. temperaturethe stirred mixture is refluxed for 3 hours
  2. customThe reaction mixture is evaporated down under reduced pressure
  3. stirringthe residue is stirred in a 1:1:1 mixture of ether, methyl tert-butyl ether and petroleum ether
  4. filtrationFiltration under suction
  5. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-bb8e3767acd04bac92d20a790155029f
Quelldatensatz
uspto-grants-1993_11
Patentnummer
US05262384

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