5-Chloro-1-benzofuran → 5-Chloro-2,3-dihydro-1-benzofuran
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1>CCO.[Rh]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
5-Chloro-benzofurane (2 g, 13.11 mmol) in dry EtOH (20 ml) was hydrogenated over 10% Rh/C (251 mg) catalyst at room temperature under atmospheric pressure. When H2 absorption ceased the catalyst was filtered off and the filtrate was concentrated in vacuo to give 1.84 g (91%) of (33) as a colourless solid. 1H-NMR (80 MHz, CDCl3) δ 7.00 (d, 2H, J=8.53 Hz), 6.62 (d, 1H, J=8.53), 4.5 (t, 2H), 3.11 (t, 2H).
Aufarbeitung
- customWhen H2 absorption
- filtrationwas filtered off
- concentrationthe filtrate was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-479282472fb84b2692964152d1140bd8
- Quelldatensatz
- uspto-grants-1993_11
- Patentnummer
- US05262430
Notizen zur Reaktion
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