Water → Methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate
Reaktionsgleichung
[N:1]([CH2:4][C:5]1[CH:23]=[CH:22][C:8]([O:9][CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>O1CCCC1>[NH2:1][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[C:11]([O:13][CH3:14])=[O:12])=[CH:22][CH:23]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of the product of Step E in dry tetrahydrofuran is treated protionwise with triphenylphosphine (1 equivalent). The solution is stirred under N2 at ambient temperature. After about 2 hours, when gas evolution has ceased, H2O (1 equivalent) is added, and the solution is concentrated in vacuo, and the residue is chromatographed on silica gel to give the title compound.