Sodium Hydroxide → 2-nitromethylenetetrahydro-2H-1,3-thiazine

HRID 258550

Reaktionsgleichung

Reaktionsgleichung von HRID 258550
[N+:1]([C:4](=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)C(OCC)=O)([O-:3])=[O:2].[OH-].[Na+]>C(O)(=O)C>[N+:1]([CH:4]=[C:10]1[NH:15][CH2:14][CH2:13][CH2:12][S:11]1)([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 71443329Ethyl nitro(1,3-thiazinan-2-ylidene)acetate

Produkt 1

HCID 428532-nitromethylenetetrahydro-2H-1,3-thiazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2.3 g of 1A was added to 10 ml of 20% aqueous sodium hydroxide and the mixture was stirred at room temperature for 12 hours. The resulting solution was treated dropwise with 3.5 g of acetic acid. The addition was accompanied by vigorous gas evolution. The resulting mixture was extracted with methylene chloride and the extract was dried (magnesium sulfate) and concentrated under reduced pressure to give tetrahydro-2-(nitromethylene)-2H-1,3-thiazine (1B) as a pale yellow solid, m.p. 76°-78°.

Aufarbeitung

  1. additionThe addition
  2. extractionThe resulting mixture was extracted with methylene chloride
  3. dry with materialthe extract was dried (magnesium sulfate)
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ecbbf5c76427496194d2c544b27b633b
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04033952

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