Water → 2-Phenyl-4-(beta-hydroxyethyl)thiazole

HRID 258577

Reaktionsgleichung

Reaktionsgleichung von HRID 258577
[C:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][C:13](OCC)=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[C:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][CH2:13][OH:14])[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 2797666Ethyl 2-(2-phenyl-1,3-thiazol-4-yl)acetateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 106083152-Phenyl-4-(beta-hydroxyethyl)thiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Reduction of the latter ester to the title compound is effected as follows: The ester (159 g) is dissolved in dry tetrahydrofuran (250 ml) and added dropwise during 30 min to a stirred mixture of lithium aluminum hydride (50 g) in tetrahydrofuran. The mixture is stirred for one hour, cooled and water (150 ml) is slowly added. The mixture is dried over magnesium sulfate and evaporated to give the title compound as a yellow oil, γmaxCHCl3 3610, 3420 and 1520 cm- 1.

Aufarbeitung

  1. temperaturecooled
  2. dry with materialThe mixture is dried over magnesium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f3d911fa4f342a987c166e3d11b4fc7
Quelldatensatz
uspto-grants-1977_07
Patentnummer
US04033977

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