Sodium hydride → Sodium 1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)pyrimidine-5-carboxylate

HRID 25867Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 25867
[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[C:6](=[O:11])[C:7]=1[C:8]([OH:10])=[O:9].CC1N=CN(C2C=CC(C)=CC=2)C(=O)C=1C(OCC)=O.[H-].[Na+:40]>C(COC)OC.CCOCC>[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:12]2[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[C:6](=[O:11])[C:7]=1[C:8]([O-:10])=[O:9].[Na+:40]

Komponenten

6

Edukt 3

HCID 24758Sodium hydrideHCID 213254901,6-Dihydro-4-methyl-6-oxo-1-(4-tolyl)pyrimidine-5-carboxylic acidHCID 21325495Ethyl 1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)pyrimidine-5-carboxylate

Produkt 1

HCID 23684865Sodium 1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)pyrimidine-5-carboxylateAusbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

A mixture of 8.0 g (0.033 mole) of 1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)pyrimidine-5-carboxylic acid, prepared from ethyl 1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)pyrimidine-5-carboxylate by the hydrolysis method of Example 2, and one equivalent of sodium hydride (added as mineral oil dispersion), slurried in 300 ml of glyme is stirred at ambient temperature for 3 days. The solid product is isolated by filtration, slurried in ether and reisolated to give after drying 5.0 g (57% yield) of sodium 1,6-dihydro-4-methyl-6-oxo-1-(4-tolyl)pyrimidine-5-carboxylate, m.p. 208°-10° C. dec.

Aufarbeitung

  1. customThe solid product is isolated by filtration
  2. customto give

Quellen und Nachweise

ORD-Eintrag
ord-3daef18a793e446e9d422b3c51603dd1
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04147528

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